The domestic economic slowdown and demographic dividend gradually faded. Arousing the enthusiasm of factors of production is the core of the reform of the supply side, and labor is part of the factors of it, so social security plays an important role on employment. The paper analyzes the asymmetric influence of regional fiscal social security expenditure on the employment based on the real GDP per capita, which are sampled from annual provincial data between 1998 and 2014, and provides a theoretical basis for the reform of the supply side. The study shows that the influence of regional fiscal social security expenditure on the employment differs in the stage of economic development.