In the context of full liberalization of the the universal two-child policy, women's fertility desire are paid more and more attention, and what factors affect the fertility and the protection of women's rights and interests become a hot topic of social concern. In this paper, the Markov model is used to predict the influence of fertility willingness and selection of the transition probability between influencing factors of fertility. The economic factors are no longer the primary factors in the face of fertility problems, while physical health and the protection of women's rights and interests are of great concern. According to the results of the model analysis, the paper proposes: the appropriate protection of women's rights; strengthening the top floor design and perfecting the supporting measures of two children; vigorously promoting the development of honest service industry and creating friendly working atmosphere.