The recent decades witness the emergence of a large number of self-employed individuals, whilst the traditional employee-society is gradually shrinking. The work structure under the employee system has also been subverted and disintegrated. Individuals and organizations have constantly improved their understanding of the work. The understanding and definition of post-employees' social work, taking the industrial age as the starting point, should be reconstructed so as to assist relevant groups to reshape their work thinking by reconstructing the historical changes and cognitive shifts of the work space, work ethics, work style, and work relationship. The work space has shifted from materialization to the virtualization. The "place effectiveness" of the physical office space owned by a single employer shifts to the needs of employees and corporate culture. The meaning of work has been given a variety of expressions, from focusing on external values to paying more attention to the internal ones, from "self-interest" to "altruism." Accordingly, the traditional human resource management system, characterized by fixed positions and bureaucratic management, is giving way to task-distribution and flexible employment-oriented work management programs. Thus, employees form more alliances with their enterprises, and future human resource management in the corporate will be focused on promoting "leading the work" and "activating workers" as its mission.