In the post-COVID-19 era, online teaching has become a major means of teaching strategies of colleges and universities, and will continue to play a key role. At the same time, many problems have been exposed and need to solved. This study analyzed the current situation of online teaching of colleges and universities from aspects of students, teachers, platform technology, and management system, and put forward suggestions for optimizing online teaching of colleges and universities. The research argues, although online teaching meets the requirements of teaching development and is conducive to the transformation of the traditional learning models, it also brings problems such as lack of teacherstudent interaction and lack of standards and norms for teaching management. This study suggests that measures such as, combining online and offline teaching, improving teachers' online teaching competence, improving the technical level of platform services, reforming the teaching management system, and improving basic services should be adopted to further optimize the effects of online teaching of colleges and universities.