As a major organizational change, transform of independent colleges has a signifi cant impact on the immediate interests of teachers. This study, based on cognitive appraisal theory and that of the resource conservation, examines the impact of uncertainty avoidance on teachers' job insecurity in the context of the upcoming transform of independent colleges, and analyzes its mediating role of perceived shock and the moderating role of human capital. This study fi nds that uncertainty avoidance has a signifi cant positive impact on teachers' sense of insecurity in their job; the perceived transfer shock of indepent colleges plays a partial intermediary role between uncertainty avoidance and teachers' sense of insecurity in their job; human capital negatively regulates the relationship between uncertainty avoidance and the perceived transfer shock; moreover, human capital also has a negative intermediary role on the perceived transfer shock between uncertainty avoidance and teachers' sense of insecurity in their job. In order to ensure the smooth progress of transformation of independent colleges, this study suggests that colleges should fully communicate with teachers about the transformation, while teachers should improve their human capital level and enhance their ability to withstand external environmental shocks.